# Biostimulator learning maps — taxonomy · equivalence · name-decode · mnemonics

> Learning aid (renders in Obsidian). Verify vs IFU. **None are reversible** (not HA → hyaluronidase useless).
>
> **Canonical mnemonics → `mnemonics.md`** · recall deck (spaced repetition) → `recall.md`. The §4 hooks below are the in-context subset.

## 0. Master idea
**Biostimulators grow YOUR OWN collagen (neocollagenesis), not instant volume.** Classify by
**chemistry**, **reversibility (none)**, **onset**, **longevity**, **sessions**.

```mermaid
mindmap
  root((Biostimulator))
    Chemistry
      PLLA poly-L-lactic acid
        Sculptra · Lanluma
      CaHA calcium hydroxylapatite
        Radiesse
      PCL polycaprolactone
        Ellansé · Gouri
      PDLLA
        AestheFill · Juvelook · Lenisna
      Hybrid CaHA+HA
        HArmonyCa
    Mechanism
      Immediate volume + stimulation = CaHA
      Pure delayed stimulation = PLLA
    Reversibility
      NONE PLLA/CaHA/PCL - key safety
    Longevity
      PLLA ~2 yr
      CaHA ~1-1.5 yr
      PCL 1-4 yr by strand
    Related not true FBR
      Profhilo = bioremodeler
      Plinest/Rejuran = polynucleotide/PDRN
```

## 1. The class ladder (by mechanism & duration)
| Chemistry | Example | Onset | Longevity | Sessions | Reversible | Note |
|---|---|---|---|---|---|---|
| CaHA | Radiesse | immediate + delayed | ~1–1.5 yr | 1 | no | volume NOW + collagen |
| PLLA | Sculptra, Lanluma | delayed (weeks) | ~2 yr | 2–3 | no | reconstitute + massage |
| PCL | Ellansé S/M/L/E | immediate gel + delayed | 1/2/3/4 yr | 1 | no | longest |
| PDLLA | AestheFill, Juvelook | delayed | ~1–2 yr | 1–2 | no | amorphous (less nodule?) |
| Hybrid | HArmonyCa | immediate + delayed | ~1.5 yr | 1 | HA part only | CaHA+HA+lidocaine |

## 2. Cross-brand equivalence
| Class | Products (≈ swappable within class) |
|---|---|
| PLLA | Sculptra ≈ Lanluma (V face / X body) ≈ AestheFill/PDLLA |
| CaHA | Radiesse · Radiesse(+) · hyperdilute for skin |
| PCL | Ellansé (S<M<L<E = 1<2<3<4 yr) ≈ Gouri (liquid) |
| PDLLA + HA | Juvelook ≈ Lenisna |
| Hybrid | HArmonyCa (CaHA + HA) |

## 3. Name-decode
```mermaid
mindmap
  root((Names))
    Sculptra = SCULPT collagen slowly PLLA
    Radiesse = RADIance radius = immediate CaHA
    Ellansé = élan momentum/long = longest PCL; S/M/L/E = 1/2/3/4 yr
    Lanluma = luma = light/volume; V face, X body
    Gouri = liquid PCL Korea, Dexlevo
    AestheFill = aesthetic fill PDLLA
    Juvelook / Lenisna = VAIM Korea PDLLA + HA
    HArmonyCa = Harmony + Ca calcium hybrid
    Profhilo = PRO + filo thread = spreads, bioremodel
```

## 4. Mnemonics (hooks)
- **Sculptra** = "**eSCULPt**" slowly (PLLA) → no volume day 1, collagen over months; 2–3 sessions, ~2 yr.
- **Radiesse** = "**RADIant now + later**" (CaHA) → immediate lift + stimulation; ~1 yr; 1 session.
- **Ellansé** = "**élan = the longest**" (PCL); letters = years → **S/M/L/E = 1/2/3/4 yr**.
- **HArmonyCa** = "**Ca = calcium**" → CaHA+HA hybrid, has lidocaine (partly HA-reversible).
- **Lanluma** = "**luma = light/volume**"; **V = face, X = body** (X = extra).
- **Profhilo** = "**PRO + hilo (thread)**" → flows, no lumps; a bioremodeler, NOT a true biostimulator.
- **KEY SAFETY:** none reversible (not HA) → hyaluronidase useless → dose conservatively, correct plane, massage protocol; nodule = triamcinolone ± 5-FU (PLLA nodule → monopolar RF).

## 5. In the xlsx
`biostimulator-map.xlsx` → **Catalogue** default-sorts by **Chemistry / Class** (PLLA/CaHA/PCL). See
**Indication × Product** (zone → biostimulator + depth) + **Substitutability**.


<!-- panorama-tiein -->
## New — 2026 panorama tie-in

> Cross-catalog hub: `panorama.md`. Reconstitution + dose-per-zone: sheet 09. None reversible (PLLA/CaHA/PCL/PDLLA). AEMPS CE registry: 43 SKUs.