# Skinbooster / polynucleotide / exosome learning maps — EN

> Learning aid (Obsidian). Not volume → skin quality / regeneration. Verify vs IFU.
>
> **Canonical mnemonics → `mnemonics.md`** · recall deck (spaced repetition) → `recall.md`.

## 0. Master idea
**These treat SKIN QUALITY / regeneration, not volume.** Four families: HA boosters/bioremodelers,
polynucleotides/PDRN, exosomes/secretomes, mesotherapy cocktails. Honesty gradient: hydration <
bioremodeling < regeneration.

```mermaid
mindmap
  root((Skin quality))
    HA boosters / bioremodelers
      Profhilo NAHYCO
      Restylane Vital
      Juvederm Volite / SkinVive
      Belotero Revive
      Saypha Rich
    Amino-acid + HA
      Sunekos
      Jalupro
    Polynucleotide / PDRN
      Plinest / Newest Mastelli
      Rejuran PharmaResearch
      Nucleofill Promoitalia
      PhilArt Croma
      Renefil TOV
    Exosome / secretome
      Purasomes
      Exocobio ASCE+
    Mesotherapy cocktails
      NCTF 135HA Fillmed
      Cytocare Revitacare
      Mesohyal Mesoestetic
```

## 1. What each family does (evidence-honest)
| Family | Mechanism | Evidence | Best use |
|---|---|---|---|
| HA booster | hydration + mild remodel | SkinVive = only Level II RCT | glow, fine lines |
| Bioremodeler | Profhilo = signalling neocollagenesis | Level IV mostly, in-vitro | skin laxity, spread |
| Polynucleotide / PDRN | tissue repair, A2A receptor | Level III–IV, growing | quality, under-eye, scars |
| Exosome / secretome | EV signalling | weak, regulatory grey | adjunct only |
| Meso cocktail | vitamins/AA/HA | mixed | revitalization |

## 2. Name-decode + mnemonics
```mermaid
mindmap
  root((Names))
    Profhilo = PRO + filo thread = spreads, no lumps
    Sunekos = eco-system + amino acids
    Jalupro = jal hyal + pro amino acids
    NCTF = New Cellular Treatment Factor 135HA
    Plinest / Newest = poly-nucleotide Mastelli
    Rejuran = rejuvenate salmon DNA Korea
    Nucleofill = nucleo DNA fill
```
- **Profhilo** = flows, no lumps, bioremodeler; fixed BAP points.
- **Sunekos / Jalupro** = HA + amino acids → build collagen/elastin scaffold.
- **Plinest / Rejuran / Nucleofill / PhilArt** = **PN / PDRN = DNA repair** salmon/trout → "nucleo = DNA".
- **SkinVive** = the ONE with a real RCT.
- **Exosomes** = careful: clinic "exosomes" are EV-enriched, not true ISEV exosomes; FDA-warned.

## 3. In the xlsx
`skinbooster-map.xlsx` → Catalogue sorts by Class/Technology. See Indication × Product + Substitutability.


<!-- panorama-tiein -->
## New — 2026 panorama tie-in

> Cross-catalog hub: `panorama.md`. Dose-per-point (BAP vs nappage vs papule): sheet 09. AEMPS CE registry: 64 SKUs. PN salmon vs trout — fish allergy.